Extraction and purification of oridonin from Rabdosia rubescens and its protective effect on intracerebral hemorrhage-induced brain injury in rats

Oridonin was extracted and purified from Rabdosia rubescens its protective effect on intracerebral hemorrhage (ICH)-induced brain injury in rats investigated. The were divided into sham, model, low-dose oridonin, middle-dose oridonin high-dose groups. ICH-induced model established latter four After modeling, the low-, middle- groups treated with 10, 20, 40 mg/kg at 2h 24 h after respectively. Results showed that, 48 compared group, modified Neurological Severity Score significantly decreased (P < 0.05), water content tissue tumor necrosis factor α, interleukin 1β, 6 nuclear factor-kappa B (NF-κB) p65 protein levels erythroid 2-related 2 (Nrf2) heme oxygenase 1 (HO-1) increased 0.05). In conclusion, can mitigate rats. mechanism may be related to reduction of inflammatory response oxidative stress by inhibiting NF-κB pathway promoting Nrf2/HO-1 antioxidant tissues.